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Clinical management

Prognostic factors for persistent fatigue after COVID-19

  • A prospective cohort study investigated prognostic factors for persistent fatigue after mild COVID-19 infection during the first wave of the pandemic.

  • Low educational level, absence of a partner, high neuroticism, low resilience, high frequency of GP contact and threatening experiences in the past were prognostic factors for persistent fatigue.

  • When a patient presents with fatigue after COVID-19 infection and meets some of the prognostic criteria, GPs should be aware of the increased risk of fatigue becoming persistent and consider this when advising on management.


WiseGP Actions:

  • Do you have support available for patients experiencing persistent fatigue? Is this something that your PCN occupational therapy team could help with? Have a look at our Wise General Practice Story, OTs and Chronic Pain Support for inspiration (!


Read more about the research informing this GEM here:


Antivirals in high-risk patients with COVID-19


  • A trial aimed to establish the safety, effectiveness and cost-effectiveness of molnupirvair, an oral antiviral, for SARS-CoV-2 in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19.

  • Molnupiravir did not reduce the frequency of COVID-19-associated hospitalisations or death among high-risk vaccinated adults in the community.

WiseGP Actions

  • Being a research active practice open to participating in similar trials could help improve the evidence base to combat future public health emergencies.

o   What research is your practice involved in, across your PCN, regionally or nationally? If you’re not research-active, is this something you could consider?

o   Could a discussion of research within general practice form a useful foundation for a GP tutorial discussion?

Read more here:

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